Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5585663 | Current Opinion in Genetics & Development | 2017 | 8 Pages |
Abstract
Chromatin is organized and segmented into a landscape of domains that serve multiple purposes. In contrast to transcription, which is controlled by defined sequences at distinct sites, DNA damage can occur anywhere. Repair accordingly must occur everywhere, yet it is inevitably affected by its chromatin environment. In this review, we summarize recent work investigating how changes in chromatin organization facilitate and/or guide DNA double-strand break repair. In addition, we examine new live cell studies on the dynamics of chromatin and the mechanisms that regulate its movement.
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Authors
Andrew Seeber, Susan M Gasser,