Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5585750 | International Journal of Developmental Neuroscience | 2017 | 37 Pages |
Abstract
The neuroprotective properties of neural stem cells (NSCs) and the paracrine signaling of mesenchymal stem cells (MSCs) have been examined in multiple pre-clinical trials of ALS with promising results. The data from these initial trials indicate a reduction in the rate of disease progression. The mechanism through which stem cells achieve this reduction is of major interest. Here, we review the to-date pre-clinical and clinical therapeutic approaches employing stem cells, and discuss the most promising ones.
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Authors
Joanna Czarzasta, Aleksandra Habich, Tomasz Siwek, Adam CzapliÅski, Wojciech Maksymowicz, Joanna Wojtkiewicz,