Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5585779 | International Journal of Developmental Neuroscience | 2017 | 7 Pages |
Abstract
Our results confirm that DVD deficiency leads to changes in multiple neurotransmitter systems in the neonate brain. Importantly, this regionally-based assessment in DVD-deficient neonates identified both widespread neurotransmitter changes (glutamine/noradrenaline) and regionally selective neurotransmitter changes (dopamine/serotonin). Thus, vitamin D may have both general and local actions depending on the neurotransmitter system being investigated. Taken together, these data suggest that DVD deficiency alters neurotransmitter systems relevant to schizophrenia in the developing rat brain.
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Authors
James P. Kesby, Karly M. Turner, Suzanne Alexander, Darryl W. Eyles, John J. McGrath, Thomas H.J. Burne,