Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5586112 | Placenta | 2017 | 7 Pages |
Abstract
Placental sFLT-1 expression is upregulated in approximately 28% of non-preeclamptic pregnancies complicated by SGA infants. These pregnancies showed increased placental vascular pathology, more umbilical Doppler abnormalities, and earlier delivery with lower birthweight. A subgroup of non-preeclamptic fetal growth restriction with upregulated sFlt-1 expression may share a common pathogenic pathway with preterm preeclampsia. This subgroup is worthy of additional study.
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Authors
Melissa Spiel, Saira Salahuddin, Elizabeth Pernicone, Zsuzsanna Zsengeller, Alice Wang, Anna M. Modest, S. Ananth Karumanchi, Jonathan L. Hecht,