Early- and late-onset preeclampsia and the tissue-specific epigenome of the placenta and newborn

Article ID	Journal	Published Year	Pages	File Type
5586153	Placenta	2017	11 Pages	PDF

Abstract

This study shows differential methylation in UC-WBC and placental tissue in EOPE as compared to PTB, identifying DMPs that are associated with cardiovascular system pathways. Future studies should examine these loci and pathways in more detail to elucidate the associations between prenatal PE exposure and the cardiovascular disease risk in offspring.

Keywords

PBS IPA MACS EWAS HUVEC FGR PTB EOPE FDR DMPS CPGs PCA Fetal programming cardiovascular disease Ingenuity Pathway Analysis Principal component analysis DAVID Preterm birth Human umbilical vein endothelial cells confidence interval DNA methylation Fetal growth restriction false discovery rate odds ratio basepairs database for annotation, visualization and integrated discovery Early-onset preeclampsia Late-onset preeclampsia Preeclampsia LOPE

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Developmental Biology

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Early- and late-onset preeclampsia and the tissue-specific epigenome of the placenta and newborn

Authors

Emilie M. Herzog, Alex J. Eggink, Sten P. Willemsen, Roderick C. Slieker, Kim P.J. Wijnands, Janine F. Felix, Jun Chen, Andrew Stubbs, Peter J. van der Spek, Joyce B. van Meurs, Régine P.M. Steegers-Theunissen,