Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5586300 | Placenta | 2017 | 8 Pages |
Abstract
We demonstrated a remarkable role of miR-34a as a regulator of NFATC1-associated placental inflammation through direct targeting of RCAN1. MiR-34a could serve as a novel therapeutic target for limiting the progression of placental inflammation after fetal cardiac bypass.
Keywords
NF-κBmiRNA-34aVECsNFATc1Rcan1Regulator of Calcineurin 1VCAM-1IκBαqRT-PCRICAM-1Sirt1mRNAHUVECSMiR-34amessenger RNAinflammationcardiopulmonary bypassFetusmicroRNAsHuman umbilical vein endothelial cellsEndothelial cellsVascular endothelial cellsnuclear factor of activated T-cellsnuclear factor kappa-Buntranslated regionintercellular adhesion molecule-1vascular cell adhesion molecule-1MicroRNAMiRNAquantitative real-time polymerase chain reactionPlacental insufficiency
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Authors
Hai-Yun Yuan, Cheng-Bin Zhou, Ji-Mei Chen, Xiao-Bing Liu, Shu-Sheng Wen, Gang Xu, Jian Zhuang,