Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5586723 | Bone Reports | 2017 | 8 Pages |
Abstract
Biomechanical axial compression tests were performed on cylindrical trabecular samples cored out of the third lumbar vertebra of each animal at the end of the study. The biomechanical test results demonstrated that a normal (positive correlation between bone mineral density and bone strength) apparent material property relationship was maintained in the lumbar spine of ODN and ALN treated non-human primates (NHP). Trabecular bone hard tissue Young's modulus value was estimated using experimentally measured stiffness combined with FEA. The FEA and experimental results demonstrated that ODN treatment for 20Â months maintained normal trabecular bone material hard tissue properties in the OVX-monkeys and was comparable to ALN.
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Authors
Antonio Cabal, Donald S. Williams, Richa Y. Jayakar, Jingru Zhang, Swanand Sardesai, Le T. Duong,