| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5586818 | Cytokine | 2017 | 7 Pages |
Abstract
The higher IL-6 levels in IBS and more specifically in IBS-D suggests a pro-inflammatory phenotype in these patients, while this phenomenon is not supported by the polymorphism of IL-6 (-G174C). Increased IL-6 in IBS might be an acquired phenomenon or mediated by other genotypes. Any potential association between gene polymorphisms and IL-6 levels in IBS should be tested by assessing both IL-6 levels and IL-6 (-G174C) simultaneously in the same IBS subjects compared to their healthy controls. Categorizing patients based on their circulating IL-6 levels may introduce a new opportunity for personalized anti-inflammatory therapies of IBS.
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Authors
Mohammad Bashashati, Maryam Moradi, Irene Sarosiek,