The good and the bad faces of STAT1 in solid tumours

Article ID	Journal	Published Year	Pages	File Type
5586875	Cytokine	2017	9 Pages	PDF

Abstract

Signal transducer and activator of transcription (STAT) 1 is part of the Janus kinase (JAK)/STAT signalling cascade and is best known for its essential role in mediating responses to all types of interferons (IFN). STAT1 regulates a variety of cellular processes, such as antimicrobial activities, cell proliferation and cell death. It exerts important immune modulatory activities both in the innate and the adaptive arm of the immune system. Based on studies in mice and data from human patients, STAT1 is generally considered a tumour suppressor but there is growing evidence that it can also act as a tumour promoter. This review aims at contrasting the two faces of STAT1 in tumourigenesis and providing an overview on the current knowledge of the underlying mechanisms or pathways.

Keywords

CDK TNBC MMP MDR MCA Jnk CTL PD-L1 MEF DAMP FGF ERK HDAC TLR MUC FADD Bcl TGF PRR HIF SOCS CXCL RIG-1 SHP2 IRF IRES ISG IFNGR MDSC TRAF TRADD XIAP Erb-B2 Receptor Tyrosine Kinase 2 Tumour-associated macrophage BCL2-associated agonist of cell death PIAS pStat CUG IRDS TNF methylcholanthrene receptor interacting protein kinase Janus kinase natural killer c-Jun N-terminal kinase IFNAR Mdm2 MHC class I NFκB STAT Danger-associated molecular pattern interferon IFN interleukin BAD TAM transforming growth factor Toll-like receptor cluster of differentiation retinoblastoma internal ribosome entry site Triple negative breast cancer Tumour suppressor suppressor of cytokine signalling Dendritic cells myeloid-derived suppressor cell Cytokine signalling interferon regulatory factor tumour necrosis factor Fas Ligand FasL Hypoxia-inducible factor Vascular endothelial growth factor Vascular Endothelial Growth Factor (VEGF)fibroblast growth factor nuclear factor kappa B TRAIL cytotoxic T lymphocyte B-cell lymphoma TNF-related apoptosis-inducing ligand matrix metalloproteinase Signal transducer and activator of transcription programmed death-ligand 1 Programmed cell death Multidrug resistance Mucin mouse double minute 2 homolog mouse embryonic fibroblast MicroRNA MiRNA Immune surveillance histone deacetylase RIP X-linked Inhibitor of Apoptosis Protein Fas-associated protein with death domain JAK interferon-stimulated gene Major histocompatibility complex class I extracellular signal-regulated kinase cyclin-dependent kinase Estrogen receptor death receptor PRR, Pattern recognition receptor