Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5586989 | Cytokine | 2017 | 8 Pages |
Abstract
Leptospirosis is a severe zoonosis which immunopathogenesis is poorly understood. We evaluated correlation between acute form of the disease and the ratio of the anti-inflammatory cytokine IL-10 to the pro-inflammatory TNF-α and IL-1β expression during the early phase of infection comparing resistant mice and susceptible hamsters infected with two different species of virulent Leptospira. The IL-10/TNF-α and IL-10/IL-1β expression ratios were higher in mouse compared to hamster independently of the Leptospira strain, suggesting a preponderant role of the host response and notably these cytokines in the clinical expression and survival to leptospirosis. Using an IL-10 neutralization strategy in Leptospira-infected mouse model, we also showed evidence of a possible role of this cytokine on host susceptibility, bacterial clearance and on regulation of cytokine gene expression.
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Authors
Mariko Matsui, Louise Roche, Marie-Estelle Soupé-Gilbert, Milena Hasan, Didier Monchy, Cyrille Goarant,