| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5587242 | Diabetes Research and Clinical Practice | 2017 | 23 Pages |
Abstract
Although the association of the R430W variation with T2D in the OOA population did not reach significance, based upon the broadened pH profile of R430W PC2, we speculate that the presence of this substitution may result in altered processing of PCSK2 substrates, ultimately leading to increased conversion to diabetes.
Keywords
Exome Sequencing ProjectPCSK2Carboxypeptidase Egenomic evolutionary rate profilingOOANGTgERPMAFSIFTESPCPEIGTExACimpaired glucose toleranceDiabetesnormal glucose toleranceminor allele frequencySorting Intolerant From Tolerantprohormone convertaseprohormone convertase 2Exome Aggregation ConsortiumGlucagonGlucose
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Authors
Alexandra Winters, Bruno Ramos-Molina, Timothy S. Jarvela, Laura Yerges-Armstrong, Toni I. Pollin, Iris Lindberg,