Chronic administration of apple polyphenols ameliorates hyperglycaemia in high-normal and borderline subjects: A randomised, placebo-controlled trial

Article ID	Journal	Published Year	Pages	File Type
5587369	Diabetes Research and Clinical Practice	2017	33 Pages	PDF

Abstract

Chronic AP administration significantly improved impaired glucose tolerance in high-normal and borderline subjects. Larger and/or longer-term scale human studies are required to confirm the potential glucose homeostasis of AP.

Keywords

HbA1c APC LDL-C HOMA-IR T2DM ALT HDL-C IFG GLP-1 NGT γ-GTP IGT DPP-4 PAI-1 OGTT IL-6 LPS Apple procyanidins FPG γ-glutamyl transpeptidase Oral glucose tolerance test AST Aspartate aminotransferase Alanine aminotransferase ALP Alkaline phosphatase impaired glucose tolerance Impaired fasting glycaemia homeostasis model assessment of insulin resistance interleukin-6 Cardiovascular diseases normal glucose tolerance triglyceride tumour necrosis factor-alpha Type 2 diabetes mellitus Dipeptidyl peptidase-4 CVD body mass index BMI TNF-α Fasting plasma glucose lactate dehydrogenase LDH high-density lipoprotein cholesterol lipopolysaccharide Plasminogen activator inhibitor-1 haemoglobin A1c Apple polyphenols total cholesterol Low-density lipoprotein cholesterol

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Endocrinology

Chronic administration of apple polyphenols ameliorates hyperglycaemia in high-normal and borderline subjects: A randomised, placebo-controlled trial

Authors

Toshihiko Shoji, Mitsuhiro Yamada, Tomisato Miura, Kazuaki Nagashima, Kasane Ogura, Nobuya Inagaki, Mari Maeda-Yamamoto,