Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5587492 | Frontiers in Neuroendocrinology | 2017 | 67 Pages |
Abstract
Loss of ovarian function in women is associated with sleep disturbances and cognitive decline, which suggest a key role for estrogens and/or progestins in modulating these symptoms. The effects of ovarian hormones on sleep and cognitive processes have been studied in separate research fields that seldom intersect. However, sleep has a considerable impact on cognitive function. Given the tight connections between sleep and cognition, ovarian hormones may influence selective aspects of cognition indirectly, via the modulation of sleep. In support of this hypothesis, a growing body of evidence indicates that the development of sleep disorders following menopause contributes to accelerated cognitive decline and dementia in older women. This paper draws from both the animal and human literature to present an integrated view of the effects of ovarian hormones on sleep and cognition across the adult female lifespan.
Keywords
DMSSWSSWANHPHFSWCSTovariectomizedOVX5-CSRTTDNMSREMNREMPRHGnRHaNOPdNMPPVTPFCHPCHRTDRLDMPAβMTLPSR17β-estradiolβ-AmyloidPsychomotor vigilance testGonadotropin-releasing hormone agonistSleep lossestradiol benzoateEstrogensElectroencephalographyHumanAlzheimer’s diseasedelayed matching-to-sampledelayed nonmatching-to-sampleWisconsin Card Sorting TestRodentMemoryRecognition memoryWorking memoryrapid eye movementnon-rapid eye movementslow-wave sleepestrogen replacement therapyRamslow-wave activityprefrontal cortexEntorhinal cortexperirhinal cortexMedial temporal lobeSleep deprivationnon-human primatePrimateEEGERTfollicular stimulating hormonehormone replacement therapyFSHHippocampusPSGDelayed responseProgesteronePolysomnogramRadial-arm mazehot flashesexecutive functionMenopause
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Endocrinology
Authors
Nicole J. Gervais, Jessica A. Mong, Agnès Lacreuse,