Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5587498 | Frontiers in Neuroendocrinology | 2016 | 31 Pages |
Abstract
The stress dampening effects of exogenous oxytocin in humans have been well documented. However, the relation between endogenous oxytocin and cortisol is poorly understood. We conducted a meta-analysis on the correlation between oxytocin and cortisol levels measured at baseline (k = 24, N = 739). The effect size for the baseline correlation statistic was small (Pearson r = 0.163, p = 0.008), with high heterogeneity (I2 = 67.88%). Moderation analysis revealed that studies where participants anticipated an experimental manipulation evidenced a greater positive correlation compared to those that did not (Pearson r = 0.318, p = 0.006). A supplementary analysis including additional studies indicated that oxytocin levels in unextracted samples were 60 times higher when using this questionable practice. The findings suggest that the interplay between oxytocin and cortisol is dynamic and sensitive to the anticipation of stress or novelty. Furthermore, extraction of oxytocin appears to be an essential methodological practice.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Endocrinology
Authors
Christopher A. Brown, Christopher Cardoso, Mark A. Ellenbogen,