Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5587626 | General and Comparative Endocrinology | 2017 | 18 Pages |
Abstract
Epigenetic modifications are classified as heritable and reversible chemical modifications of chromatin that do not cause changes in DNA sequence. Changes in epigenetic modifications can be caused by exposure to certain environmental factors, such as contaminants like bisphenol A (BPA). Bisphenol A is ubiquitous in the environment and produced in large quantities, and known to have hormone-like activity, whereby disrupting endocrine function. Because of evidence for disruption of sex steroid mediated pathways, there is a concern that BPA could have adverse effects on female reproduction. The purpose of this review is to summarize the effects of BPA on adult female reproduction with focus on epigenetic changes that can be heritable.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Endocrinology
Authors
Stefania Santangeli, Francesca Maradonna, Ike Olivotto, Chiara Carla Piccinetti, Giorgia Gioacchini, Oliana Carnevali,