Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5587844 | General and Comparative Endocrinology | 2017 | 29 Pages |
Abstract
Peptide YY (PYY) functions as a postprandial satiety signal in mammals. However, the genomic information and physiological roles of chicken PYY have not yet been clarified, although PYY peptide was isolated from chicken intestines in 1992. In this study, we identified a full-length complementary DNA (cDNA) sequence encoding the chicken PYY precursor. The deduced amino acid sequence of chicken PYY was completely consistent with the previously identified peptide sequence. PYY mRNA was abundantly expressed in the small intestine compared with the large intestine. PYY mRNA levels in the jejunum were significantly higher during ad libitum feeding compared with fasting, suggesting that intestinal PYY expression is altered in response to nutritional status in chicks. Intravenous administration of PYY significantly suppressed food intake in chicks. Furthermore, neuropeptide Y receptor Y2, a possible target of PYY, was expressed in various brain regions including the appetite-regulating centers in chicks. This is the first evidence that the intestinal hormone PYY may function as an anorexigenic hormone in chicks.
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Biochemistry, Genetics and Molecular Biology
Endocrinology
Authors
Koji Aoki, Makoto Kondo, Mika Okuda, Takaoki Saneyasu, Kazuhisa Honda, Hiroshi Kamisoyama,