The timing of administration of exogenous glucocorticoid affects 24Â hour growth hormone secretion in children

Short-term prednisolone 5 mg administered in the morning may alleviate nocturnal GH suppression as compared to evening administration. In analogy, growth rates are less affected by morning as compared to evening administration of exogenous glucocorticoids. In contrast, collagen markers and metabolic indices were not affected by the timing of prednisolone administration.