Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5588322 | Metabolism | 2017 | 32 Pages |
Abstract
Our study demonstrated that LPS-induced cardiac contractile dysfunction is associated with the robust suppression of catabolism of energy substrates including FAs, glucose and ketone bodies and accumulation of glycogen and triacylglycerol in the heart. Thus, a fuel shift from FAs to glucose and/or ketone bodies may be detrimental rather than protective under septic conditions.
Keywords
LCADTumor necrotic factor-αFABPNEFAβ-hydroxybutyrateDKOIL-1βG1PPPARαMCADGAPDHTCAα-KGLPSα-ketoglutarateAdenosine TriphosphateATPtricarboxylic acidFatty acidNon-esterified fatty acidInterleukin-1βtriacylglyceroldouble knock outMedium-chain acyl-CoA dehydrogenaseLong-chain acyl-CoA dehydrogenaseSepsisCardiac functionTNF-αlipopolysaccharideEnergy metabolismNADwild typenicotinamide adenine dinucleotideBOHFatty acid binding proteinGlucoseglyceraldehyde 3-phosphate dehydrogenasePeroxisome proliferator activated receptor α
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Authors
Yogi Umbarawan, Mas Rizky A.A. Syamsunarno, Hideru Obinata, Aiko Yamaguchi, Hiroaki Sunaga, Hiroki Matsui, Takako Hishiki, Tomomi Matsuura, Norimichi Koitabashi, Masaru Obokata, Hirofumi Hanaoka, Anwarul Haque, Fumio Kunimoto, Yoshito Tsushima,