Performance of first trimester biochemical markers and mean arterial pressure in prediction of early-onset pre-eclampsia

Article ID	Journal	Published Year	Pages	File Type
5588328	Metabolism	2017	28 Pages	PDF

Abstract

Based on our results, the best first trimester biomarkers to predict the subsequent EO-PE were AFP, PlGF, RBP4 and sTNFR1. The risk models that performed best for the prediction of EO-PE included prior risk, MAP, sTNFR1 and AFP or PlGF or RBP4.

Keywords

FPR Fstl3 IUGR TGF-β Early onset pre-eclampsia PAPP-A SHBG sP-selectin PlGF RBP4 STNFR1 angiopoietin-2 SGA ROC IGF AUC Soluble P-selectin Ang-2 alpha fetoprotein Transforming Growth Factor Beta AFP tumor necrosis factor alpha Small for gestational age gestational age Coefficient of Variation placental growth factor Pregnancy complication Vascular endothelial growth factor Vascular Endothelial Growth Factor (VEGF)Insulin-like growth factor TNF-α mean arterial pressure intrauterine growth restriction area under the curve Detection rate False positive rate map receiver operating characteristics pre-eclampsia retinol binding protein-4 Insulin-like growth factor binding protein-4 pregnancy associated plasma protein-A Sex hormone-binding globulin