Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5588353 | Metabolism | 2017 | 32 Pages |
Abstract
Cortisol concentrations after a doubling of the dose were only dose proportional for free cortisol. HC pharmacokinetics can differ up to 10-fold inter-individually and individual adjustment of treatment doses may be necessary. Doubling of the HC dose in fast metabolizers (patients that showed relative low AUC and thus high clearance compared to other patients), does not result in significantly enhanced exposure during large parts of the day and these patients may need other management strategies.
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Authors
Jorien Werumeus Buning, Daan J. Touw, Pauline Brummelman, Robin P.F. Dullaart, Gerrit van den Berg, Melanie M. van der Klauw, Jasper Kamp, Bruce H.R. Wolffenbuttel, André P. van Beek,