Effect of a single bout of aerobic exercise on high-fat meal-induced inflammation

Article ID	Journal	Published Year	Pages	File Type
5588355	Metabolism	2017	30 Pages	PDF

Abstract

Results indicate that the single bout of moderate aerobic exercise increased AMPK signaling in PBMCs, as shown by increased phosphorylated acetyl-CoA carboxylase (p-ACC). This may be due to decreases in the AMPK inhibitory kinases PKD and GSK3Î². Additionally, prior moderate intensity exercise decreased postprandial lipemia (PPL) and some mediators of the inflammatory pathway, such as p-NF-ÎºB. These findings that acute aerobic exercise improves AMPK and NF-ÎºB signaling in human PBMCs contribute support to the anti-inflammatory roles of exercise.

Keywords

TBST PVDF HDL ERK BCA ECL p38 T2D RFC PBMCs AMPK GSK3β IκBα FFAs BIA VO2 peak PKD PPL HFM TRIS-buffered saline with Tween 5-aminoimidazole-4-carboxamide ribonucleotide PBS AICAR ACC Jnk NF-κB SDS AMP activated protein kinase AMP-activated protein kinase AUC c-Jun N-terminal kinase MAPK ROS bicinchoninic acid assay acetyl-CoA carboxylase Free fatty acids enhanced chemiluminescence cardiovascular disease bioelectrical impedance analysis analysis of variance ANOVA Triglycerides Peak oxygen uptake polyvinylidene difluoride Type 2 diabetes CVD sodium dodecyl sulfate peripheral blood mononuclear cells body mass index BMI nuclear factor-κB nuclear factor kappa B Phosphate buffered saline phosphorylated Postprandial lipemia LDL High-density lipoproteins low-density lipoproteins area under the curve High-fat meal protein kinase D mitogen-activated protein kinase extracellular-signal-regulated kinase Glycogen synthase kinase 3β Reactive oxygen species