Metabolic syndrome enhances endoplasmic reticulum, oxidative stress and leukocyte-endothelium interactions in PCOS

Article ID	Journal	Published Year	Pages	File Type
5588356	Metabolism	2017	34 Pages	PDF

Abstract

Our findings support the hypothesis of an association between altered metabolic status, increased ROS production, ER stress and leukocyte-endothelium interactions in PCOS, all of which are related to vascular complications.

Keywords

NF-κB PMNs GRP78 HDLC DHEAS hsCRP ATF6 PCOS XBP1 UPR VCAM-1 LDLc DCFH-DA ICAM-1 HUVECS SHBG IL-6 Dehydroepiandrosterone-sulfate ROS apo apolipoprotein Homeostatic model assessment Endoplasmic reticulum stress inflammation interleukin 6 cardiovascular disease tumor necrosis factor alpha Endothelial function dichlorodihydrofluorescein diacetate CVD Human umbilical vein endothelial cells Polycystic ovary syndrome Metabolic syndrome body mass index BMI endoplasmic reticulum TNF-α nuclear factor kappa B activating transcription factor 6 polymorphonuclear leukocytes METS Insulin resistance Intercellular adhesion molecule 1 Vascular cell adhesion molecule 1 follicle-stimulating hormone luteinizing hormone sex hormone binding globulin FSH HOMA Unfolded protein response X-box binding protein 1 high sensitivity C-reactive protein high density lipoproteins cholesterol Low density lipoproteins cholesterol Reactive oxygen species

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Endocrinology

Metabolic syndrome enhances endoplasmic reticulum, oxidative stress and leukocyte-endothelium interactions in PCOS

Authors

Celia Bañuls, Susana Rovira-Llopis, Aranzazu Martinez de Marañon, Silvia Veses, Ana Jover, Marcelino Gomez, Milagros Rocha, Antonio Hernandez-Mijares, Victor M. Victor,