Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5588364 | Metabolism | 2017 | 24 Pages |
Abstract
Acute, pre-ischemic exposure to high fat significantly lowers post-ischemic cardiac recovery vs. no fat despite identical reperfusion conditions. These findings support the concept that oxidation of residual fatty acids is rapidly restored upon reperfusion and exacerbates ischemia-reperfusion (IR) injury. Strategies to optimize post-ischemic cardiac recovery should take pre-ischemic fat levels into consideration.
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Authors
Petra Niederberger, Emilie Farine, Maria Arnold, Rahel K. Wyss, Maria N. Sanz, Natalia Méndez-Carmona, Brigitta Gahl, Georg M. Fiedler, Thierry P. Carrel, Hendrik T. Tevaearai Stahel, Sarah L. Longnus,