Neovascular deterioration, impaired NADPH oxidase and inflammatory cytokine expression in adipose-derived multipotent cells from subjects with metabolic syndrome

Article ID	Journal	Published Year	Pages	File Type
5588366	Metabolism	2017	37 Pages	PDF

Abstract

Our findings suggest a redox imbalance status in ASCs from subjects with metabolic syndrome and decreased their neovascular function that probably contributes to the vascular insufficiency of adipose depots.

Keywords

ASC APC CEBPα PPARγ HOMA-IR GPT FCS SOD1 SOD3 HUVECS MCP1 NADPH PE-Cy7 EBM FITC RPL13A ribosomal protein L13A HGF FBS Mip1α GGT SASP CCAAT/enhancer binding protein α NOx ROS γ-glutamyltransferase allophycocyanin GOT glutamic oxaloacetic transaminase fetal bovine serum fetal calf serum Human umbilical cord vein endothelial cells Metabolic syndrome body mass index BMI Hepatocyte growth factor Vascular endothelial growth factor Vascular Endothelial Growth Factor (VEGF)phycoerythrin fluorescein isothiocyanate Senescence-associated secretory phenotype endothelial basal medium nicotinamide adenine dinucleotide phosphate macrophage inflammatory protein 1 alpha HDL-cholesterol LDL-cholesterol glutamate pyruvate transaminase Reactive oxygen species peroxisome proliferator activated receptor γ

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Endocrinology

Neovascular deterioration, impaired NADPH oxidase and inflammatory cytokine expression in adipose-derived multipotent cells from subjects with metabolic syndrome

Authors

Wilfredo Oliva-Olivera, Said Lhamyani, Leticia CoÃn-Aragüez, Daniel Castellano-Castillo, Juan Alcaide-Torres, Elena MarÃa Yubero-Serrano, Rajaa El Bekay, Francisco José Tinahones,