Article ID Journal Published Year Pages File Type
5588406 Metabolism 2017 24 Pages PDF
Abstract
We report here that global deletion of a key downstream receptor for POMC peptide, the melanocortin 4 receptor (MC4R), did not affect normal negative feedback regulation of estrogen on the HPG axis, estrous cyclicity and female fertility. Furthermore, loss of the MC4R did not influence estrogenic regulation on food intake and body weight. These results indicate that the MC4R is not required for estrogen's effects on metabolic and reproductive functions.
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Endocrinology
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