Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5588436 | Metabolism | 2017 | 30 Pages |
Abstract
These results suggest that 12Â weeks of pioglitazone treatment improves insulin sensitivity, metabolic flexibility and myocellular lipid distribution without any effect on maximal ATP synthetic capacity in skeletal muscle. Consequently, pioglitazone-induced enhancements in insulin responsiveness and fuel utilization are independent of mitochondrial function.
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Authors
Sudip Bajpeyi, Magdalena Pasarica, Kevin E. Conley, Bradley R. Newcomer, Sharon A. Jubrias, Cecilia Gamboa, Kori Murray, Olga Sereda, Lauren M. Sparks, Steven R. Smith,