Angiopoietin-like protein 2 is a positive regulator of osteoblast differentiation

Article ID	Journal	Published Year	Pages	File Type
5588449	Metabolism	2017	38 Pages	PDF

Abstract

The results suggest that Angptl2 is an autocrine positive regulator of cell differentiation. Thus, it is suggested that Angptl2 regulates not only adipose tissue metabolism but also bone metabolism.

Keywords

NF-κB NEAA Angiopoietin-like protein 2 β-GP α-MEM AP2 Angptl2 TRAP ERK MMP-9 RANKL RUNX2 GAPDH DMEM LPS SDS PVDF Jnk FBS cDNA MAPK Dulbecco's modified Eagle's medium siRNA β-Glycerophosphate Adipocyte ALP Alkaline phosphatase Osteoblast complementary deoxyribonucleic acid small interfering ribonucleic acid tartrate-resistant acid phosphatase Differentiation tumor necrosis factor-α polyvinylidene difluoride Real time-PCR fetal bovine serum Mesenchymal stem cell endoplasmic reticulum Runt-related transcription factor 2 TNF-α nuclear factor kappa B lipopolysaccharide Matrix metalloproteinase-9 Real time polymerase chain reaction mitogen-activated protein kinase adaptor protein 2 Jun amino-terminal kinase extracellular signal-regulated kinase glyceraldehyde-3-phosphate dehydrogenase receptor activator of nuclear factor kappa-B ligand

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Life Sciences Biochemistry, Genetics and Molecular Biology Endocrinology

Angiopoietin-like protein 2 is a positive regulator of osteoblast differentiation

Authors

Aiko Takano, Takao Fukuda, Takanori Shinjo, Misaki Iwashita, Etsuko Matsuzaki, Kensuke Yamamichi, Masaaki Takeshita, Terukazu Sanui, Fusanori Nishimura,