Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5588603 | Nutrition Research | 2017 | 31 Pages |
Abstract
We recently reported the in vitro and in vivo antiobesity effects of Tenebrio molitor larvae, a traditional food in many countries, but it remains unknown how the larvae affect appetite regulation in mice with diet-induced obesity. We hypothesized that the extract of T molitor larvae mediates appetite by regulating neuropeptide expression. We investigated T molitor larvae extract's (TME's) effects on anorexigenesis and endoplasmic reticulum (ER) stress-induced orexigenic neuropeptide expression in the hypothalami of obese mice. Intracerebroventricular TME administration suppressed feeding by down-regulating the expression of the orexigenic neuropeptides neuropeptide Y and agouti-related protein. T molitor larvae extract significantly reduced the expression of ER stress response genes. These results suggest that TME and its bioactive components are potential therapeutics for obesity and ER stress-driven disease states.
Keywords
ATF4spliced X-box binding protein 1S6 kinase 1phosphorylated signal transducer and activator of transcription 3Erdj4Janus Kinase 2SOCS3LFDGRP78eIF2αJAK2intracerebroventricularPOMCPDImTORTMEHFDNPYICVAgRPC/EBP-homologous proteinMAPKAppetiteCHOPhigh-fat dietlow-fat dietsuppressor of cytokine signaling 3endoplasmic reticulumactivating transcription factor 4Neuropeptidemammalian target of rapamycinHypothalamusRibosomal protein S678 kDa glucose-regulated proteinprotein disulfide isomerasemitogen-activated protein kinaseproopiomelanocortinagouti-related peptidediet-induced obesityNeuropeptide Y
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Authors
Minchul Seo, Jongwan Kim, Seong-Su Moon, Jae-Sam Hwang, Mi-Ae Kim,