Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5589249 | Gene | 2017 | 26 Pages |
Abstract
The minor A allele of vaspin rs2236242 polymorphism plays a protective role against obesity and diabetes but this relation is largely ascribed to its effect on insulin resistance. The serum vaspin concentration was lower in minor protective allele carriers. To the best of our knowledge, this is the first study of vaspin SNP in Upper Egyptian women. The entire understanding of vaspin intimate mechanistic action might enable the development of novel etiology-based treatment strategies for obesity, the complex genetic trait.
Keywords
HDL-Chs-CRPT2DMT-ARMS-PCRLDL-CHOMA-IRALTalanine transaminasehomeostasis model assessment of insulin resistanceWAT, White adipose tissueCardiovascular diseasesDiabetesTriglyceridesType 2 diabetes mellitusCVDWorld Health Organizationbody mass indexBMIconfidence intervalObesityWaist/hip ratioodds ratiohigh sensitivity C-reactive proteinSingle nucleotide polymorphismSNPWATWHO
Related Topics
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Biochemistry, Genetics and Molecular Biology
Genetics
Authors
Soad M. Abdel Ghany, Ayat A. Sayed, Sahar E.M. El-Deek, Hala M. ElBadre, Marwa A. Dahpy, Medhat A. Saleh, Hanan Sharaf El-Deen, Mohamed H. Mustafa,