A genome-wide transcriptomic analysis of articular cartilage during normal maturation in pigs

During the process of articular cartilage maturation from 6-weeks to 6-months of age in normal pigs, genes associated with inflammatory responses to injury were upregulated and genes involved in the development and vascular responses were downregulated. These findings suggest that during articular cartilage maturation, the transcriptional changes might increase the susceptibility of cartilage to inflammatory damage and decrease the regenerative capacity.