| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5589705 | Gene | 2017 | 4 Pages |
Abstract
Emerging evidence indicates that alcohol intake is associated with human cancers in different organs. However, the molecular mechanism of alcohol-associated human cancers remains to be elucidated. Here, this paper aimed to clarify a novel mechanism of alcohol-promoted cell transformation and tumor development. Alcohol induces JNK1 activation and increases cellular levels of c-Jun to upregulate Brf1 expression and Pol III gene transcription, leading to an enhancement of rates of cell transformation and tumor formation.
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Authors
Ganggang Shi, Shuping Zhong,