Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5590118 | Genomics | 2016 | 8 Pages |
Abstract
To elucidate important cellular and molecular interactions that regulate patterning and skeletal development, vertebrate limbs served as a model organ. A growing body of evidence from detailed studies on a subset of limb regulators like the HOXD cluster or SHH, reveals the importance of enhancers in limb related developmental and disease processes. Exploiting the recent genome-wide availability of functionally confirmed enhancer dataset, this study establishes regulatory interactions for dozens of human limb developmental genes. From these data, it appears that the long-range regulatory interactions are fairly common during limb development. This observation highlights the significance of chromosomal breaks/translocations in human limb deformities. Transcriptional factor (TF) analysis predicts that the differentiation of early nascent limb-bud into future territories entail distinct TF interaction networks. Conclusively, an important motivation for annotating the human limb specific regulatory networks is to pave way for the systematic exploration of their role in disease and evolution.
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Authors
Shahid Ali, Bibi Amina, Saneela Anwar, Rashid Minhas, Nazia Parveen, Uzma Nawaz, Syed Sikandar Azam, Amir Ali Abbasi,