Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5591868 | Molecular Immunology | 2017 | 13 Pages |
Abstract
After exposure, macrophages phagocytise pathogens, activate the complement cascade and the adaptive immune system through the antigen presentation process. However, data presented here suggest that genes related to phagocytosis and lysosome function are down regulated in MAP infected MDM. Genes of MHC class II and complement pathway were also down-regulated. This study therefore shows that MAP infection is associated with changes in expression of genes related to the host immune response that may affect its ability to survive and multiply inside the host cell.
Keywords
Arg2IFNGR1CSFsITGA2IFNGR2CSF2ITGB3iNOSCIITAIfngγδ T cellsarginase 2interleukinJohne’s diseaseCrohn’s diseaseGamma delta T cellsgranulocyte-macrophage colony-stimulating factorColony-stimulating factorsgranulocyte colony-stimulating factorMACmapnitric oxide synthase 2Gene ontologymembrane attack complexDifferentially expressed genesCISHInterferon gamma
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Authors
Rosanna Marino, Rossana Capoferri, Simona Panelli, Giulietta Minozzi, Francesco Strozzi, Erminio Trevisi, Gustavo G.M. Snel, Paolo Ajmone-Marsan, John L. Williams,