| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5591874 | Molecular Immunology | 2017 | 10 Pages |
Abstract
Innate immunity consists of several kinds of pathogen recognition receptors (PRRs), which participate in the recognition of pathogens and consequently activation of innate immune system against pathogens. Recently, several investigations reported that PRRs may also play key roles in the induction/stimulation of immune system related complications in microbial infections. Hepatitis B virus (HBV), as the main cause of viral hepatitis in human, can induce several clinical forms of hepatitis B and also might be associated with hepatic complications such as cirrhosis and hepatocellular carcinoma (HCC). Based on the important roles of PRRs in the eradication of microbial infections including viral infections and their related complications, it appears that the molecules may be a main part of immune responses against viral infections including HBV and participate in the HBV related complications. Thus, this review article has brought together information regarding the roles of PRRs in immunity against HBV and its complications.
Keywords
NF-κBAcLDLHSCEGFLPSPBMCMYD88CDCBECPDCCpG-ODNNADPHDAMPPAMPsCTDCRDAP-1TLRPRRLTAMBLDAIIRAK1TRAF6NLRDMBT1MNDAKCSTBK1RIG-IDC-SIGNTAK1MDA5SR-BIOBIAIM2fMLPoxLDLIFI16LRRLOX-1lectin-like oxidized LDL receptor-1DNA methyltransferase 1RLRsLGP2Plasmacytoid DCDNMT-1BDCA-2CTLDsE-selectinIPS-1LipopolysacharideDMXAAZbp1Soluble L-selectinHIN5,6-dimethylxanthenone-4-acetic acidN-formylmethionyl-leucyl-phenylalaninemyeloid cell nuclear differentiation antigenSCARA5sl-selectinsoluble E-selectinHCCMAPKdamage associated molecular patternslipoteichoic acidInnate immunityTANK binding kinase 1Leucine-rich repeatsTIRToll-like receptorcarbohydrate recognition domainPeripheral blood mononuclear cellKupffer cellsbiliary epithelial cellsHepatic stellate cellsCirrhosisepidermal growth factorTNF receptor associated factorOccult HBV infectionnuclear factor kappa-light-chain-enhancer of activated B cellsMannose-binding lectinOxidized low density lipoproteinsstimulator of interferon genesDendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrinSTINGnicotinamide adenine dinucleotide phosphateHBVabsent in melanoma 2Hepatitis B virus (HBV)hepatitis B viruspathogen associated molecular patternsactivator protein 1mitogen-activated protein kinasemelanoma differentiation-associated gene 5retinoic acid-inducible gene 1CARDHepatocellular carcinomaToll/interleukin-1 receptorScavenger receptorNOD-like receptorspattern recognition receptorspathogen recognition receptors
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Authors
Reza Nosratabadi, Seyed Moayed Alavian, Mohammad Zare-Bidaki, Vahid Mohammadi Shahrokhi, Mohammad Kazemi Arababadi,