Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5593712 | Physiology & Behavior | 2017 | 23 Pages |
Abstract
Results showed that adolescent morphine treatment significantly facilitates the development of tolerance to the analgesic effect of morphine and increases morphine withdrawal signs (grooming, head tremor, sniffing, scratching and teeth chattering) in adulthood compared to the saline group. Facilitation of morphine tolerance and potentiation of withdrawal signs suggests that chronic escalating morphine treatment during adolescence causes long-lasting effects on development of morphine tolerance and dependence in adulthood.
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Authors
Hamed Salmanzadeh, Hossein Azizi, Saeed Semnanian,