Rapamycin Decreases the Osteogenic Response inÂ Aortic Valve Interstitial Cells Through the Stat3Â Pathway

Article ID	Journal	Published Year	Pages	File Type
5597654	The Annals of Thoracic Surgery	2016	10 Pages	PDF

Abstract

Rapamycin inhibits TLR4-induced osteogenic responses in AVICs by activation of Stat3 through Akt. Rapamycin may alleviate inflammation-induced initiation and progression of CAVD.

Keywords

LPS mTOR RUNX2 BMP-2 STAT3 Aortic valve interstitial cells TLR4 CAVD ALP Alkaline phosphatase calcific aortic valve disease Runt-related transcription factor 2 lipopolysaccharide signal transducer and activator of transcription 3 mammalian target of rapamycin bone morphogenetic protein 2 Toll-like receptor 4

Related Topics

Health Sciences Medicine and Dentistry Cardiology and Cardiovascular Medicine

Preview

Rapamycin Decreases the Osteogenic Response inÂ Aortic Valve Interstitial Cells Through the Stat3Â Pathway

Authors

Xin-Sheng MD, Xianzhong MD, PhD, Rui MD, PhD, David MD, James MD,