| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5597656 | The Annals of Thoracic Surgery | 2016 | 8 Pages |
Abstract
Altered expression of particular miRs selectively in the affected tissue indicate their role as factors that trigger pathways of aneurysmal transformation. Limited reparative properties due to overexpression of miR-191 may play a crucial role for aneurysm enlargement, whereas nitric oxide-dependent relaxation of vascular smooth muscle mediated by miR-21 offers an attractive explanation of the aneurysm's initiation, and is confirmed in experimental conditions.
Keywords
ECMNOS3MMPTAAVSMCmRNAmessenger RNAThoracic aortic aneurysmrepeated measures analysis of varianceRANOVAVascular smooth muscle cellVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)Extracellular matrixmatrix metalloproteinaseMicroRNAnitric oxide synthasepolymerase chain reactionPCR
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Authors
Sabina MD, Michal MS, Boguslaw MD, PhD, Marek MD, PhD,