Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5599230 | Atherosclerosis | 2017 | 9 Pages |
Abstract
These results suggest that LPS may increase Ac-LDL uptake and enhance CD204 expression through MAPK/ERK activation and CD36 expression through an ERK-independent pathway. Since MEK inhibitors block CD204 expression in mouse BM macrophages only under LPS treatment but not under normal conditions, a MEK inhibitor might be a good candidate compound for the treatment of LPS-induced atherosclerosis.
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Authors
Ryota Hashimoto, Ryo Kakigi, Kyoko Nakamura, Seigo Itoh, Hiroyuki Daida, Takao Okada, Youichi Katoh,