HDL inhibits saturated fatty acid mediated augmentation of innate immune responses in endothelial cells by a novel pathway

Article ID	Journal	Published Year	Pages	File Type
5599419	Atherosclerosis	2017	36 Pages	PDF

Abstract

These results indicate that endothelial cell innate immune responses are modified by metabolic abnormalities commonly present in insulin resistance and provide evidence for a novel mechanism by which HDL may reduce vascular inflammation.

Keywords

CEBP HAECs MIP-1α IL-8 ATF3 PKC MβCD IL-1β ERK HDL PI3K LPS DAMPs IL-6 NF-κB Jnk MAPKs TLRs saturated fatty acid inflammation interleukin 1 beta interleukin 6 Interleukin 8 human aortic endothelial cells Cell signaling nuclear factor kappa B phosphoinositide 3-kinase activating transcription factor 3 lipopolysaccharide methyl-beta-cyclodextrin damage-associated molecular pattern molecules quantitative real-time PCR Palmitic acid macrophage inflammatory protein 1 alpha Protein kinase C MAP kinase extracellular-signal-regulated kinase mitogen-activated protein kinases Toll-like receptors