| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5599441 | Atherosclerosis | 2016 | 9 Pages |
Abstract
n-3 PUFAs suppressed atherogenesis. DHA combined with EPA had additional anti-inflammatory effects and inhibited atherogenesis in Apoeâ/â mice. The reduction of TLR4 expression in lipid rafts in macrophages by DHA might be involved in this mechanism, at least partially.
Keywords
MβCDVCAM1MMP9TLR4MCP1TFREPATNFαLPSApoE−/−n-3 PUFAAtherosclerosisEicosapentaenoic aciddocosahexaenoic acidn-3 polyunsaturated fatty acidinflammationtumor necrosis factor αDHALipid raftlipopolysaccharideMatrix metalloproteinase 9Macrophagemethyl-beta-cyclodextrinVascular cell adhesion molecule 1monocyte chemoattractant protein 1transferrin receptorToll-like receptor 4
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Authors
Akira Takashima, Daiju Fukuda, Kimie Tanaka, Yasutomi Higashikuni, Yoichiro Hirata, Sachiko Nishimoto, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Yutaka Taketani, Michio Shimabukuro, Masataka Sata,