| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5599493 | Atherosclerosis | 2017 | 40 Pages |
Abstract
Blocking ligand binding to the αVβ3 integrin inhibits its activation and attenuates increased VSMC proliferation that is induced by chronic hyperglycemia. These changes result in significant decreases in atherosclerotic lesion size in the coronary arteries. The results suggest that this approach may have efficacy in treating the proliferative phase of atherosclerosis in patients with diabetes.
Related Topics
Health Sciences
Medicine and Dentistry
Cardiology and Cardiovascular Medicine
Authors
L.A. Maile, W.H. Busby, G. Xi, K.P. Gollahan, W. Flowers, N. Gafbacik, S. Gafbacik, K. Stewart, E.P. Merricks, T.C. Nichols, D.A. Bellinger, D.R. Clemmons,