| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5599648 | Atherosclerosis | 2017 | 9 Pages |
Abstract
This study reveals a role for vascular P2Y2R as an inhibitor of arterial intimal calcification and provides a new mechanistic insight into the regulation of the osteoblastic trans-differentiation of SMC through P2Y2R-mediated Runx2 antagonism. Given that calcification of atherosclerotic lesions is a significant clinical problem, activating P2Y2R may be an effective therapeutic approach for treatment or prevention of vascular calcification.
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Authors
Shaomin Qian, Jenna N. Regan, Maxwell T. Shelton, April Hoggatt, Khalid S. Mohammad, Paul B. Herring, Cheikh I. Seye,