Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5602546 | Heart, Lung and Circulation | 2017 | 9 Pages |
Abstract
Brief, non-harmful ischaemic insults to an organ remote from the heart, remote ischaemic preconditioning (RIPC), has been proposed to confer protection to the heart against ischaemia-reperfusion injury. While most clinical trials of RIPC during coronary interventions (PCI) suggest benefit, recent large, multicentre trials in coronary artery bypass surgery suggest a lack of efficacy. Mechanistically, RIPC most likely promotes the release of circulating factors which modulate multiple cellular pathways in the heart, promoting cell survival. This review explores potential mechanisms underlying RIPC and includes a contemporary evaluation of clinical studies in PCI and cardiac surgery, highlighting methodological differences which may explain discrepant findings between these two clinical groups.
Keywords
MACCEHsp-70STEMISDF-1αRemote ischaemic preconditioningPCIRIPCIPCPKCERKHIF-1ALDH-2Ischaemic preconditioningIschaemia reperfusion injuryAldehyde dehydrogenase-2STATST elevation myocardial infarctionischaemia-reperfusionSAFEcoronary artery bypass graftingreperfusion injury salvage kinasecoronary artery bypass grafting surgeryCABGmajor adverse cardiac and cerebrovascular eventsRiskmicro ribonucleic acidextracellular signal regulated kinasesHeat shock protein-70hypoxia inducible factor-1Signal transducer and activator of transcriptionpercutaneous coronary interventionMiRNAProtein kinase C
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Authors
Jerrett K. MBBS, Gabrielle J. PhD, Andy PhD, Leonard PhD,