Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5603146 | Heart Rhythm | 2016 | 8 Pages |
Abstract
Mathematical simulations based on a population of models representing intersubject variability allow the identification of ionic mechanisms underlying rotor dynamics and the definition of new personalized pharmacologic strategies. Our results suggest that the underlying mechanism of the diverging success of ICaL block as an antiarrhythmic strategy is dependent on the basal availability of sodium and calcium ion channel conductivities.
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Authors
Alejandro PhD, Alfonso PhD, Miguel MS, Ursula MD, Ismael MS, Francisco MD, PhD, Maria S. PhD, Blanca PhD, Andreu M. PhD,