Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5603343 | Heart Rhythm | 2017 | 7 Pages |
Abstract
Using an objective measure of terminal repolarization, we conclude that IK1 is the major determinant of the terminal repolarization time course. Moreover, suppression of IK1 prolongs repolarization and reduces postrepolarization refractoriness without marked effects on the overall AP duration. Collectively, these findings demonstrate how IK1 suppression may contribute to arrhythmogenesis in the failing heart.
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Authors
Michael G. PhD, Matie MD, Jayna PhD, Soroosh PhD, Myles Haigney, Richard R. PhD, Robert E. MD, Thomas P. PhD, Mark C. MD,