| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5603480 | Heart Rhythm | 2017 | 21 Pages |
Abstract
Our study showed that dantrolene beneficially influenced disrupted SR Ca2+ homeostasis in human HF and AF CM. Cellular arrhythmogenic triggers were potently suppressed by dantrolene, whereas action potential duration and contractility were not affected. As a clinically approved drug for the treatment of malignant hyperthermia, dantrolene may be a potential antiarrhythmic drug for patients with rhythm disorders and merits further clinical investigation.
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Authors
Nico MD, Steffen MS, Jonas MD, Felix MS, André MD, Jan MD, Hanna MD, Bernhard C. MD, Lars S. MD, Norbert MD, Gerd MD, Thomas H. MD, Samuel MD,