| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5603484 | Heart Rhythm | 2017 | 19 Pages |
Abstract
NADH activated PKCδ by enhancing PLD activity. PKCδ modulated both mitoROS and NaV1.5. PKCδ elevated mitoROS by enhancing mitochondrial oxidative phosphorylation complex activities. PKCδ-mediated channel phosphorylation and mitoROS were both required to down-regulate NaV1.5 and alter single channel conductance.
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Authors
Man PhD, Guangbin MD, Kai-Chien MD, PhD, Lianzhi MD, PhD, Anumantha G. PhD, Vellareddy PhD, Samuel C. MD, PhD,