LncRNA MALAT1 sponges miR-204 to promote osteoblast differentiation of human aortic valve interstitial cells through up-regulating Smad4

Article ID	Journal	Published Year	Pages	File Type
5604289	International Journal of Cardiology	2017	9 Pages	PDF

Abstract

Our study provides novel mechanistic insights into a critical role for lncRNA MALAT1 as a miRNA sponge in CAVD and sheds new light on lncRNA-directed diagnostics and therapeutics in CAVD.

Keywords

FBS RNA-binding protein immunoprecipitation VICS CAVD SMAD4 β-gal lncRNAs qRT-PCR HRP MiR-204 long non-coding RNA Long non-coding RNAs competing endogenous RNAs AVR β-galactosidase calcific aortic valve disease Aortic valve replacement RISC fetal bovine serum ceRNAs Valve interstitial cells MALAT1 RNA-Induced Silencing Complex RIP Horseradish peroxidase

Related Topics

Health Sciences Medicine and Dentistry Cardiology and Cardiovascular Medicine

Preview

LncRNA MALAT1 sponges miR-204 to promote osteoblast differentiation of human aortic valve interstitial cells through up-regulating Smad4

Authors

Xiaoxiong Xiao, Tingwen Zhou, Shichao Guo, Chao Guo, Qiao Zhang, Nianguo Dong, Yongjun Wang,