Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5604968 | International Journal of Cardiology | 2017 | 7 Pages |
Abstract
This mutation leads to a gain-of-function mechanism based on increased channel availability and increased window current, fitting the observed clinical phenotype of (likely adrenergic-induced) ventricular arrhythmias and atrial fibrillation. These findings further expand the range of cardiac arrhythmias associated with mutations in SCN5A.
Keywords
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Authors
Krystien V. Lieve, Arie O. Verkerk, Svitlana Podliesna, Christian van der Werf, Michael W. Tanck, Nynke Hofman, Paul F. van Bergen, Leander Beekman, Connie R. Bezzina, Arthur A.M. Wilde, Elisabeth M. Lodder,