| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5605208 | International Journal of Cardiology | 2017 | 10 Pages |
Abstract
Pro-atherogenic effects of aldosterone are mediated by increased ICAM-1 expression, through transcriptional regulation by endothelial MR. These data enhance our understanding of the molecular mechanism by which MR activation promotes atherosclerosis complications.
Keywords
AP-1TGF-βMREVCAM-1NF-κBHFDICAM-1HUVECAtherosclerosisAldoaldosteroneMyocardial infarctionApoeapolipoprotein ESpiroSpironolactoneTransforming growth factor βHigh fat dietHuman umbilical vein endothelial cellEndothelial cellEndothelial cellsnuclear factor kappa-light-chain-enhancer of activated B cellsintercellular adhesion molecule-1Intercellular adhesion molecule 1Vascular cell adhesion molecule 1activator protein 1Mineralocorticoid receptor
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Authors
Vincenzo Marzolla, Andrea Armani, Caterina Mammi, Mary E. Moss, Vittoria Pagliarini, Laura Pontecorvo, Antonella Antelmi, Andrea Fabbri, Giuseppe Rosano, Iris Z. Jaffe, Massimiliano Caprio,